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T Cell (CAR-T) Therapy

Cancer Treatment Options

https://www.texasoncology.com/services-and-treatments/treatments/car-t-therapy

Chimeric Antigen Receptor - (CAR-T) Therapy

Chimeric Antigen Receptor – T cell (CAR-T) therapy is one of the most exciting, promising treatment breakthroughs in recent years. Texas Oncology is one of the very few authorized centers in the country to initially provide CAR-T therapy. Learn more about how CAR-T therapy works in this video:

A type of immunotherapy, CAR-T therapy galvanizes the body’s immune system to fight cancer. It uses genetically engineered immune T cells to recognize specific proteins on tumor cells. Some of a patient’s white blood cells are extracted, modified, and replicated so that they recognize and attack cancer cells. View an infographic from The Leukemia & Lymphoma Society that explains CAR-T therapy here.

Car T-cell Therapy

Eligible Patients

CAR-T provides another treatment option when standard treatments are not effective. Adult patients who have been diagnosed with either relapsed or refractory large B-cell lymphoma, a type of non-Hodgkin lymphoma, or acute lymphocytic leukemia, and who have failed two or more types of therapy may be eligible. CAR-T clinical trials may be available for other hematologic malignancies or solid tumors, including non-Hodgkin lymphoma, acute lymphocytic leukemia, multiple myeloma, chronic lymphocytic leukemia, pancreatic cancer, and others.

Texas Oncology offers CAR-T therapy at two Dallas area locations, through collaborations with Baylor University Medical Center and Medical City Dallas Hospital.

Request an Appointment or More Information

Patients interested in CAR-T therapy should contact:

Telemedicine

Patients who are eligible for CAR-T treatment and who live outside the Dallas area may be able to access CAR-T treatment experts via telemedicine, in conjunction with a local Texas Oncology physician in the patient’s community. In some cases, patients could receive initial consultations and assistance with managing aspects of follow-up care via telemedicine. While this may provide added convenience for out-of-town patients, patients will need to travel to Dallas for treatment. Learn more about telemedicine.

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CAR-T Therapy Frequently Asked Questions

CAR-T therapy, a type of immunotherapy, galvanizes the body’s immune system to fight cancer. Texas Oncology is one of the very few authorized centers in the country to initially provide CAR-T therapy. Following are some frequently asked questions:

Q: How does CAR-T therapy work?
A type of immunotherapy, CAR-T therapy galvanizes the body’s immune system to fight cancer. It uses genetically engineered immune T cells to recognize specific proteins on tumor cells. Some of a patient’s white blood cells are extracted, modified, and replicated so that they recognize and attack cancer cells. View an infographic that explains CAR-T therapy here.
Q: Who is eligible for CAR-T therapy?
CAR-T therapy is offered to adult patients who have been diagnosed with either relapsed or refractory large B-cell lymphoma, a type of non-Hodgkin lymphoma, or acute lymphocytic leukemia, and who have failed two or more types of therapy as another treatment option. CAR-T clinical trials may be available for other hematologic malignancies or solid tumors, including non-Hodgkin lymphoma, acute lymphocytic leukemia, multiple myeloma, chronic lymphocytic leukemia, pancreatic cancer, and others.
Q: Why is CAR-T therapy only available to non-Hodgkin lymphoma and acute lymphocytic leukemia patients at Texas Oncology?
To date, the U.S. Food and Drug Administration (FDA) has approved two forms of CAR-T cell therapy for patients with diffuse large B-cell lymphoma or acute lymphocytic leukemia. Texas Oncology–Baylor Charles A. Sammons Cancer Center is conducting multiple clinical trials to test CAR-T therapies for several types of cancer, including non-Hodgkin lymphoma, acute lymphocytic leukemia, multiple myeloma, chronic lymphocytic leukemia, pancreatic cancer, and others, through a collaboration with Baylor University Medical Center.
Q: When will CAR-T therapy be available to treat other cancer types at Texas Oncology?
Texas Oncology–Baylor Charles A. Sammons Cancer Center is conducting multiple clinical trials to test CAR-T therapies for several types of cancer, including non-Hodgkin lymphoma, acute lymphocytic leukemia, multiple myeloma, chronic lymphocytic leukemia, pancreatic cancer, and others, through a collaboration with Baylor University Medical Center.
Q: Are telemedicine consults available for CAR-T therapy?
Yes, in some cases, patients could receive initial consultations and assistance with managing aspects of follow-up care via telemedicine. While this may provide added convenience for out-of-town patients, patients will need to travel to Dallas for treatment.
Q: Where is CAR-T therapy available?
Texas Oncology offers CAR-T therapy at two Dallas area locations, including Texas Oncology–Baylor Charles A. Sammons Cancer Center and Texas Oncology–Medical City Dallas, through collaborations with Baylor University Medical Center and Medical City Dallas Hospital.
Patients who are eligible for CAR-T treatment and who live outside the Dallas area may be able to access CAR-T treatment experts via telemedicine, in conjunction with a local Texas Oncology physician in the patient’s community.
Q: Why doesn’t my oncologist provide CAR-T therapy?
Texas Oncology, in collaboration with Baylor University Medical Center and Medical City Dallas Hospital, is one of a select group of sites nationally that has been certified to provide this leading-edge treatment.
Q: How can I enroll in a CAR-T clinical trial?
A multidisciplinary selection committee guides the process for determining eligible patients for this new therapy, which takes into consideration clinical testing based on past clinical trial criteria and FDA guidelines. Patients interested in a CAR-T therapy clinical trial should contact Texas Oncology–Baylor Charles A. Sammons Cancer Center at 214-370-1999.
Q: Will insurance cover CAR-T therapy?
Texas Oncology participates in most health insurance plans, Medicare, Medicaid, and selected Health Insurance Marketplace plans. Not all plans are available at all of our cancer centers, so it's important to call your insurance company to confirm if your plan is available at Texas Oncology centers in your area. Regarding CAR-T therapy, health insurers are preparing their coverage policies for the FDA-approved CAR-T therapies. In the meantime, coverage is reviewed on a case-by-case basis, as is typical when new therapies are first approved. Our patient benefits representatives can help verify coverage for clinically-eligible patients.
Q: How can I learn more about CAR-T therapy?
Patients interested in CAR-T therapy should contact:

CAR-T Therapy Oncologists and Locations

The following Texas Oncology oncologists and locations specialize in Car-T Therapy.

Locations and Specialists

Texas Oncology-Baylor Charles A. Sammons Cancer Center
3410 Worth St., Suite 400
Dallas, TX 75246
T: 214-370-1000Texas Oncology-Baylor Charles A. Sammons Cancer Center Blood and Marrow Transplant
3410 Worth St., Suite 300
Dallas, TX 75246
T: 214-370-1500Texas Oncology-Medical City Dallas Blood and Marrow Transplant
7777 Forest Lane, Suite D220
Dallas, TX 75230
T: 972-566-7790Texas Oncology-Medical City Dallas Building D
7777 Forest Lane, Suite D400
Dallas, TX 75230
T: 972-566-7790
Source: https://www.texasoncology.com/services-and-treatments/treatments/car-t-therapy